Rumour has it Pogba wants to play on the left of a midfield 3, would be a good opportunity to try it ahead of the midweek game.
I would keep a few players fresh (Jones, Shaw, Matic, Martial) for the CL game. Mata and Sanchez potentially too with Lingard and Rashford playing.
Valencia Rojo Smalling Young
Herrera Carrick Pogba
Mata Lukaku Sanchez